Optibrium™, Intellegens and Medicines Discovery Catapult awarded funding to apply machine learning in drug discovery
CAMBRIDGE, UK, 19 September, 2018
Funding to support Artificial Intelligence (AI) in drug discovery takes a significant step forward today as Optibrium, Intellegens, and Medicines Discovery Catapult secure a grant from Innovate UK to fund a £1 million project.
The program will see Optibrium, which creates software to improve the efficiency and productivity of drug discovery, and Intellegens, a spin out from the University of Cambridge which is focused on a specific form of AI called ‘deep learning’, work with Medicines Discovery Catapult over the next two years.
The aim is to harness the power of AI to learn from complex data and guide scientists in the design and testing of potential new drugs. Drug discovery generates a huge quantity of complex biological, chemical, clinical and safety information that needs to be collected, analysed and presented in a way that it can be best used to make evidence-based decisions.
The research partners are seeking a means of providing better insights into how a drug interacts with the body, improving the efficiency and productivity of drug discovery. The project will use novel deep learning methods to create a next generation platform that will better predict the absorption, distribution, metabolism, excretion and toxicity (ADMET) of new drug candidates.
Building on Optibrium’s existing software offering (StarDrop™) and an Intellegens’ deep learning toolkit (Alchemite™), the project will develop and apply novel AI methods across ADMET. By developing DeepADMET technology the aim is to improve the scope and reliability of drug design parameters, currently inaccessible or unavailable, for the first time.
Each partner in the collaboration brings a unique skill set.
Matthew Segall, Chief Executive Officer of Optibrium, says:
“We are delighted to lead this project in collaboration with Medicines Discovery Catapult and Intellegens. We will apply cutting edge deep learning methods and new data to address important challenges in drug optimisation. The funding from Innovate UK is important validation of our project team’s expertise and the impact it will have on the industry’s efficiency and productivity. We look forward to making these models available to researchers through the StarDrop platform.”
Professor John Overington, Chief Informatics Officer of the Medicines Discovery Catapult, says:
“At Medicines Discovery Catapult we apply innovation, working alongside UK SMEs to drive the development and adoption of new approaches for the discovery and early development of new medicines. This collaborative R&D activity will allow us to do just that and the grant from Innovate UK represents an important milestone for the advancement of informatics and data science.”
Ben Pellegrini, Chief Executive Officer of Intellegens, says:
“Intellegens is extremely excited to be part of this collaboration and looks forward to applying our novel deep learning techniques to help build a next generation platform to improve the drug discovery process.”
Currently, high failure rates mean that 9 out of 10 potential drugs fail somewhere between phase 1 trials and regulatory approval, greatly adding to the costs of creating new medicines.
The growth in computer-processing power, availability of large data sets, development of advanced algorithms and major improvements in machine learning presents a great opportunity for drug discovery.
The technology and models created as a result of this project will help guide the selection and design of compounds early in the discovery process, to more quickly identify candidate drugs with a higher chance of success and lower development risk.
For further information or to arrange interviews please contact:
+44 (0) 7771 730919
+44 (0) 20 8123 4788
Medicines Discovery Catapult
+44 (0) 7971 350116
About the Medicines Discovery Catapult
The Medicines Discovery Catapult is a national centre of applied Research and Development expertise, uniquely designed to promote and support innovative, fast-to-patient drug discovery in the UK through collaborative projects.
It is one of a network of elite, not-for-profit technology and innovation centres established by Innovate UK as a long-term investment in the UK’s economy. The Medicines Discovery Catapult will work with industry, academic teams, technology experts, charities, regulators and others.
We provide unique scientific capabilities and act as a gateway to specialist facilities, technology and expertise within the UK, supporting SMEs to drive the development of new approaches for the discovery and early development of new medicines. Helping to transform ideas into commercial products and services for the wider health and wealth of the country.
By developing and validating new ways of discovering new medicines, and promoting key talent and expertise across sectors, it can help the UK maintain its heritage position as a global leader in this key industry.
Optibrium provides elegant software solutions for small molecule design, optimisation and data analysis. The company’s lead product, StarDrop, is a comprehensive suite of integrated software with a highly visual and user-friendly interface. StarDrop enables a seamless flow from the latest data through to predictive modelling and decision-making regarding the next round of synthesis and research, improving the speed, efficiency, and productivity of the discovery process.
Founded in 2009, Optibrium is headquartered in Cambridge, UK with offices in Boston and San Francisco, USA. Optibrium continues to develop new products and research novel technologies to improve the efficiency and productivity of the drug discovery process. Optibrium works closely with its broad range of customers and collaborators that include leading global pharma, agrochemical and flavouring companies, biotech and academic groups.
Optibrium™ and StarDrop™ are trademarks of Optibrium Ltd
Intellegens is a spin-out from the University of Cambridge with a unique Artificial Intelligence (AI) toolset that can train deep neural networks from sparse or noisy data. The technique, created at the Cavendish Laboratory, is encapsulated in Intellegens first commercial product, Alchemite™. The innovative deep learning algorithms that Alchemite™ is based on can see correlations between all available parameters, both inputs and outputs, in fragmented, unstructured, corrupt or even noisy datasets. The result is accurate models that can predict missing values, find errors and optimise target properties. Capable of working with data that is as little as 0.05% complete, Alchemite™ can unravel data problems that are not accessible to traditional deep learning approaches. Suitable for deployment across any kind of numeric dataset, Alchemite™ is delivering ground breaking solutions in drug discovery, advanced materials, patient analytics and predictive maintenance – enabling organisations to break through data analysis bottlenecks, reduce the amount of time and money spent on research, and support better, faster decision-making. For more information contact us here.